Endocrine Abstracts

Ordinary complication of pregnancy is shift of hepatic excretory activity leading to cholestasis. Gallstone disease is also predominated in women. Both high prolactin (Prl) concentration and high level of liver prolactin receptors (PrlR) in normal and pregnant women were assumed to participate in obstructive cholestasis development.Using female rat model of hyperprolactinemia combined with obstructive cholestasis we aimed to investigate Prl influence on ...

Gonadotropinomas secreting biologically active hormones, most commonly follicle-stimulating hormone (FSH), are a very rare pathology. The clinical manifestations depend on the gender and age of the patient. Men may observe enlarged testicles and erectile dysfunction. Reports on the results of the drug treatment are sporadic.Objective: To describe a rare clinical case of an active giant FSH-secreting pituitary tumour in a 62-year-old man with the developm...